Trial Condition(s):

Cough

Repeat doses of BAY 1817080 in healthy males & Proof of concept in chronic cough patients

Bayer Identifier:

18184

ClinicalTrials.gov Identifier:

NCT03310645

EudraCT Number:

2017-001620-22

Study Completed

Trial Purpose

To investigate the safety and tolerability of ascending repeated oral doses of BAY1817080 in healthy volunteers(Part1).
To investigate the safety, tolerability and efficacy of BAY1817080 in patients with refractory chronic cough(Part2).

Inclusion Criteria
Part 1
- Male; healthy according to complete medical history, including the physical examination, vital signs (blood pressure, pulse rate), 12 lead ECG, clinical laboratory tests
- Age: 18–45 years (inclusive) at the first screening visit.
- Non-smoker for at least the past 6 months and with a pack year history of equal to or less than 5 years.
- Subjects who are sexually active and have not been surgically sterilized must agree to use two reliable and acceptable methods of contraception simultaneously when having sexual intercourse with women of childbearing potential (one method used by the subject and one method used by the partner) during the study and for 90 days after receiving the investigational medicinal product and not to act as sperm donor for 90 days after dosing. [Acceptable methods of contraception include for example: (a) condoms (male or female) with or without a spermicidal agent, (b) diaphragm or cervical cap with spermicide, (c) intrauterine device, (d) hormone-based contraception.
Part 2:
- Age: >18 years at the first screening visit
- Refractory chronic cough for at least one year:
-- that has been shown to be unresponsive to at least 8 weeks of targeted treatment for identified underlying triggers including reflux disease, asthma and post-nasal drip or unexplained cough, and
-- for which no objective evidence of an underlying trigger can be determined after investigation.
- Score of >40 mm on the Cough Severity visual analogue scale (VAS) at screening.
- For male patients:
Male patients who are sexually active and have not been surgically sterilized must agree to use two reliable and acceptable methods of contraception simultaneously (one method used by the study patient and one method used by the partner) during the study and for 90 days after receiving the investigational medicinal product and not to act as sperm donor for 90 days after dosing. [Acceptable methods of contraception include for example: (a) condoms (male or female) with or without a spermicidal agent, (b) diaphragm or cervical cap with spermicide, (c) intrauterine device, (d) hormone-based contraception.
--For female patients:
Confirmed post-menopausal woman (defined as exhibiting spontaneous amenorrhea for at least 12 months before screening or as exhibiting spontaneous amenorrhea for 6 months before screening with documented serum follicle-stimulating hormone (FSH) levels > 40 mIU/mL)
or
Woman without childbearing potential based on surgical treatment at least 6 weeks before screening such as bilateral tubal ligation, bilateral oophorectomy with or without hysterectomy (documented by medical report verification)
or
Woman of childbearing potential that agrees to use two reliable and acceptable methods of contraception simultaneously (one method used by the study patient and one method used by the partner) during the study and for at least 10 days after the last dose. Acceptable methods of contraception include for example: (a)condoms (male or female) with or without a spermicidal agent (b)diaphragm or cervical cap with spermicide (c) intrauterine device (d)hormone-based contraception.
Exclusion Criteria
Part 1
- Relevant diseases potentially interfering with the study's aims (e.g.respiratory diseases) within the four weeks before screening or between screening and randomization
- Any febrile illness within the four weeks before screening or between screening and randomization
- Medical history of hypogeusia/dysgeusia or the subject has a dysfunction in his/her ability to taste, as revealed by the taste disturbance questionnaire during screening and the pre dose procedures
- Use of any over-the-counter cough mixture within the 24 hours before screening

Part 2:
- FEV1 or FVC of less than 60% of predicted normal, at screening
- History of upper or lower respiratory tract infection or recent significant change in pulmonary status within the 4 weeks before baseline visit.
- Current smoking habit or history of smoking within the 6 months before the screening visit.
- History of smoking (at any time) for more than 20 pack-years in total (20 cigarettes per pack)

Trial Summary

Enrollment Goal
87
Trial Dates
black-arrow
Phase
1/2
Could I receive a placebo?
Yes
Products
Eliapixant (BAY1817080)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Medicines Evaluation Unit

Manchester, United Kingdom, M23 9QZ

Status
Completed
 
Locations

Castle Hill Hospital

Cottingham, United Kingdom, HU16 5JQ

Status
Completed
 
Locations

University Hospital of South Manchester

Manchester, United Kingdom, M23 9LT

Status
Completed
 
Locations

King's College Hospital - NHS Foundation Trust

London, United Kingdom, SE5 9RS

Status
Completed
 
Locations

North Tyneside General Hospital

North Shields, United Kingdom, NE29 8NH

Status
Completed
 
Locations

Queen's University

Belfast, United Kingdom, BT9 7AB

Status
Completed
 
Locations

Birmingham Heartlands Hospital

Birmingham, United Kingdom, B9 5SS

Status
Completed
 

Trial Design