Finerenone/digoxin drug-drug interaction study
The primary objective of the study was to investigate the influence of a concomitant intake of multiple doses of 20 mg finerenone administered once-daily (od) for 10 days on the steady-state pharmacokinetics of digoxin (0.375 mg od).
The secondary objective was to assess the safety and tolerability of the combined administration of both drugs and to determine the influence of multiple doses of digoxin (0.375 mg od) on the pharmacokinetics of a single dose of 20 mg finerenone.
- Healthy male subjects, white, age: 18 to 45 years, body mass index: ≥ 18.0 and ≤ 29.9 kg/m².
No Exclusion Criteria Available
Mannheim, Germany, 68167
E-mail: [email protected]
Phone: (+)1-888-84 22937
Randomized, non-blind, non-placebo-controlled, 2-fold cross-over study with additional 1st period with fixed treatment to investigate the pharmacokinetic interaction between finerenone (20 mg once-daily) and digoxin (0.375 mg once-daily) and to investigate the safety and tolerability of the combined administration in healthy male subjects