Trial Condition(s):

Neoplasms

Clinical study to evaluate the maximum tolerated dose of BAY1000394 given in a 3 days on / 4 days off schedule in subjects with advanced malignancies

Bayer Identifier:

14484

ClinicalTrials.gov Identifier:

NCT01188252

EudraCT Number:

2010-019191-79

Study Completed

Trial Purpose

Clinical study to determine safety, tolerability, to measure how the drug is metabolized by the body and to determine the maximum tolerated dose of BAY1000394 given in an intermittent 3 days on / 4 days off schedule to patients with advanced malignancies

Inclusion Criteria
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1
 - Life expectancy of at least 12 weeks
 - Subjects with advanced, histologically or cytologically confirmed solid tumors, refractory to any standard therapy, have no standard therapy available, or subjects must have actively refused any treatment which would be regarded standard, and / or if in the judgment of the investigator, experimental treatment is clinically and ethically acceptable
 - At least 1 tumor lesion measurable by computer tomography (CT) scan or magnetic resonance imaging (MRI) according to RECIST 1.1
 - Adequate bone marrow, liver, and renal functions as assessed by the following laboratory requirements to be conducted within 14 days prior to the first dose of study drug
Exclusion Criteria
- History of cardiac disease:  congestive heart failure > NYHA Class II, unstable angina (anginal symptoms at rest), any episodes of angina or history of myocardial infarction, cardiac arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted), previous venous or arterial thrombotic events, pulmonary embolism
 - Moderate or severe hepatic impairment, i.e. Child-Pugh class B or C(3)
 - History of human immunodeficiency virus (HIV) infection or chronic hepatitis B or C
 - Active clinically serious infections of CTCAE > Grade 2 (CTCAE v4.02)
 - Symptomatic metastatic brain or meningeal tumors unless the subject is > 3 months from definitive therapy, has no evidence of tumor growth on an imaging study within 4 weeks prior to study entry, and is clinically stable with respect to the tumor at the time of study entry.  Subjects must not be on acute steroid therapy or taper off steroid therapy (chronic steroid therapy is acceptable provided that the dose is stable for 4 weeks prior to study entry and following screening CT / MRI scan).  Subjects with neurological symptoms should undergo a CT / MRI scan of the brain to exclude new or progressive brain metastases. Spinal cord metastasis is acceptable
 - Seizure disorder requiring therapy (such as steroids or anti-epileptics)
 - History of organ allograft
 - Evidence or history of bleeding disorder, i.e. any hemorrhage / bleeding event of CTCAE > Grade 2 within 4 weeks prior to prior to the first dose of study drug

Trial Summary

Enrollment Goal
112
Trial Dates
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Phase
1
Could I receive a placebo?
No
Products
Roniciclib (BAY1000394)
Accepts Healthy Volunteers
No

Where to Participate

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Locations
Status
LocationsStatus
Locations

Investigative Site

VILLEJUIF CEDEX, France, 94805

Status
Completed
 
Locations

Investigative Site

Marseille Cedex 20, France, 13915

Status
Completed
 
Locations

Investigative Site

Herne, Germany, 44625

Status
Completed
 
Locations

Investigative Site

LYON CEDEX, France, 69008

Status
Completed
 
Locations

Investigative Site

CAEN CEDEX, France, 14033

Status
Completed
 
Locations

Investigative Site

St. Louis, United States, 63110

Status
Completed
 
Locations

Investigative Site

Heidelberg, Germany, 69120

Status
Completed
 
Locations

Investigative Site

Cleveland, United States, 44195

Status
Terminated
 
Locations

Investigative Site

Buffalo, United States, 14263-0001

Status
Completed
 

Trial Design