Trial Condition(s):
Carcinoma, Non-Small-Cell Lung
Evaluation of BAY 59-8862 in Taxane Resistant Non-Small Cell Lung Cancer Patients
Bayer Identifier:
10653
ClinicalTrials.gov Identifier:
EudraCT Number:
Not Available
EU CT Number:
Not Available
Trial Purpose
Lung cancer is among the most common cancers in the world and its incidence continues to increase. Chemotherapy for patients with Non-Small Cell Lung Cancer (NSCLC) has been under investigation for several decades and several new drugs with activity in NSCLC have been identified. These include the taxanes, which are among the most commonly used class of chemotherapy agents in clinical oncology today. The usefulness of the taxanes is limited by the development of tumor resistance to these agents. This phase II trial with BAY 59-8862 will be conducted to determine the anti-tumor efficacy of BAY 59-8862 in taxane-resistant NSCLC.
Inclusion Criteria
- Measurable disease as defined by the presence of at least one measurable lesion - Patients must have received at least 3 weeks of continuous therapy with Taxane - patient must subsequently develop progressive disease either during treatment or within 6 months after treatment - Life expectancy of at least 12 weeks - Adequate bone marrow, liver and kidney function
Exclusion Criteria
- Excluded medical conditions like: pre-existing neuropathy, active heart diseases or ischemia, serious infections, HIV infection, chronic hepatitis B or C; brain metastasis, seizures, hypersensitivity to taxanes, organ transplants, some previous cancers - excluded therapies and medications, previous and concomitant such as: anticancer chemotherapy or immunotherapy during the study or within 4 weeks prior to study entry; more than two prior anticancer chemotherapy regimens; radiotherapy during study or within 4 weeks prior to study entry; bone marrow transplant. - others: pregnant or breast-feeding patients; both men and women enrolled in this trial must use adequate barrier birth control measures during the course of the trial; substance abuse, medical, psychological or social conditions that may interfere with the patient's participation.
Trial Summary
Enrollment Goal
Trial Dates
Phase
Could I receive a placebo?
Products
Accepts Healthy Volunteers
Where to Participate
| Locations | Status | |
|---|---|---|
Locations Sapir Medical Center, Meir General Hospital Kfar Saba, Israel, 44281 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Pisana Pisa, Italy, 56126 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Jayne Gurtler APMC Metairie, United States, 70006 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Charité Campus Virchow-Klinikum (CVK) Berlin, Germany, 13353 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Tel Aviv Sourasky Medical Center Tel Aviv, Israel, 64239 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. Santa Maria Misericordia UD Udine, Italy, 33100 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Norton Healthcare Pavilion Louisville, United States, 40202 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Ramón y Cajal Madrid, Spain, 28034 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Chaim Sheba Medical Center Tel Hashomer, Israel, 52621 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. S.G.Battista-Molinette Torino, Italy, 10126 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Clínic i Provincial de Barcelona Barcelona, Spain, 08036 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Arizona Clinical Research Center Tucson, United States, 85712 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. di Modena Policlinico Modena, Italy, 41100 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Roswell Park Cancer Institute Buffalo, United States, 14263-0001 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Harold Leever Cancer Center Waterbury, United States, 06708-2904 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Juravinski Cancer Centre Hamilton, Canada, L8V 5C2 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Asklepios Fachkliniken München Gauting Gauting, Germany, 82131 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital Clínico Universitario San Carlos Madrid, Spain, 28040 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hopital Laval Quebec, Canada, G1V 4G5 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital General de Elche Elche, Spain, 03203 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Northwestern Ontario Regional Cancer Centre Thunder Bay, Canada, P7A 7T1 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Tennessee Oncology, PC Nashville, United States, 37205 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Cross Cancer Institute Edmonton, Canada, T6G 1Z2 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hospital de Cruces Barakaldo, Spain, 48903 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Hematology Oncology Consultants, Inc. Columbus, United States, 43235 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations Sir Mortimer B. Davis Jewish General Hospital Montreal, Canada, H3T 1E2 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
Locations A.O.U. di Parma Parma, Italy, 43100 | Status Completed | Contact Us: E-mail: [email protected] Phone: Not Available |
For details, please refer to trial results
Additional Information
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