Carcinoma, Renal Cell

Inclusion Criteria

- measurable disease as defined by the presence of at least one measurable lesion  - prior immunotherapy (up to 2 regimens) or prior radiotherapy is permitted but at least 4 weeks must have elapsed prior to enter study  - life expectancy of at least 12 weeks  - adequate bone marrow, liver and kidney function

Exclusion Criteria

- excluded medical conditions like:  pre-existing neuropathy, active heart diseases or ischemia, serious infections, HIV infection, chronic hepatitis B or C, brain metastasis, seizures, hypersensitivity to taxanes, organ transplants, some previous cancers  - excluded therapies and medications, previous and concomitant such as:  anticancer chemotherapy or immunotherapy during the study or within 4 weeks prior to study entry; more than two prior anticancer chemotherapy regimens; radiotherapy during study or within 4 weeks prior to study entry; bone marrow transplant  - others:  pregnant or breast-feeding patients; both men and women enrolled in this trial must use adequate barrier birth control measures during the course of the trial; substance abuse, medical, psychological or social conditions that may interfere with the patient's participation.